Implementation of maximin efficient designs in dose‐finding studies
نویسندگان
چکیده
منابع مشابه
Maximin and Maximin-efficient Event-related Fmri Designs under a Nonlinear Model by Ming-hung Kao,
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Previous studies on event-related functional magnetic resonance imaging experimental designs are primarily based on linear models, in which a known shape of the hemodynamic response function (HRF) is assumed. However, the HRF shape is usually uncertain at the design stage. To address this issue, we consider a nonlinear model to accommodate a wide spectrum of feasible HRF shapes, and propose eff...
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Latin hypercube designs (LHDs) play an important role when approximating computer simulation models. To obtain good space-filling properties, the maximin criterion is frequently used. Unfortunately, constructing maximin LHDs can be quite time-consuming when the number of dimensions and design points increase. In these cases, we can use approximate maximin LHDs. In this paper, we construct bound...
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ژورنال
عنوان ژورنال: Pharmaceutical Statistics
سال: 2014
ISSN: 1539-1604,1539-1612
DOI: 10.1002/pst.1660